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br Materials and methods br Results br Discussion Previously
2022-05-20
Materials and methods Results Discussion Previously, it is well known that methionine and choline deficient (MCDD) or choline-deficient, L-amino acid-defined (CDAA) models are widely accepted in NASH research. MCDD or CDAA dietary model has been mimic human NASH in rodents by sequentially p
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Until now unfortunately no safe effective vaccine
2022-05-20
Until now, unfortunately, no safe, effective vaccine against HIV-1/AIDS has been found [16], [17]. Therefore, the development of safe, effective vaccines is a top priority in HIV/AIDS research field. Accordingly, to investigate the interactions between HIV vaccines or inhibitors and their correspond
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Recently several dual GLP GIP
2022-05-19
Recently, several dual GLP-1/GIP receptor agonists have been developed as a treatment of type II diabetes. These peptides can activate both the GLP-1 and the GIP receptor. Such dual receptor agonists are superior compared to single GLP-1 analogues such as liraglutide (Finan et al., 2013). Previously
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Ghrelin is mostly known for its orexigenic properties wherea
2022-05-19
Ghrelin is mostly known for its orexigenic properties, whereas the role of DAG on feeding is controversial with studies claiming an orexigenic, anorexigenic or no effect (Inhoff et al, 2009, Toshinai et al, 2006). One of these studies was that of Toshinai and colleagues, who found a link between the
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Introduction br Channel activity Since initial
2022-05-19
Introduction Channel activity Since initial reports of the Ca2+-activated K+ permeability of erythrocytes (see Gardos, 1958), several ‘criteria’ have been established to certify K+ fluxes as being due to the Gárdos channel. For example, the requirement for Ca2+ at the intracellular face of the c
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br Signals transmitted via MEGJ MEGJ facilitate the direct
2022-05-19
Signals transmitted via MEGJ MEGJ facilitate the direct transfer of ion currents or small molecules between EC and VSMC. Molecules passing through MEGJ are mainly second messengers such as Ca2+, IP3, and cAMP [31,32,] or endothelium-derived hyperpolarization (EDH) signals [34, 35, 36]. Moreover,
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Clinical trials of all GSIs have
2022-05-19
Clinical trials of all GSIs have ended prematurely, raising the question on our understanding of their target, the γ-secretase/presenilin. Development of compounds to target γ-secretase and reduce Aβ production is complicated by the fact that γ-secretase/presenilin has critical biological function,
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flavopiridol br Ethics approval br Availability
2022-05-19
Ethics approval Availability of data and materials Consent for publication Competing interests Authors contributions Introduction Glucose supply to tissues is maintained through a complex regulatory network mostly driven by the pancreatic hormones insulin and glucagon which control
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br General features of FGFRs and inhibitors
2022-05-19
General features of FGFRs and inhibitors Conclusion Given the critical role of FGFRs in the progression of tumors, the co-crystal structures of these kinases in complex with inhibitors are determined in order to clarify the mechanism of actions and explore new efficient inhibitors. This manusc
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Genetic contributions to this dysregulation of expression
2022-05-19
Genetic contributions to this dysregulation of expression have been studied, and significant associations have been found. The Fas −670 polymorphism is associated with preterm premature rupture of membranes, preeclampsia, as well as intrauterine growth restriction [7], [16]. The Fas SNP (−670 A>G) i
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The third group also included samples
2022-05-19
The third group also included samples belonging to subjects with undetectable viraemia, for which the negative or persistence of the indeterminate WB result in subsequent samples indicated a non-HIV infection. In this subgroup, the VITROS HIV Combo test (as well as the other two tests) was negative
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Allergic rhinitis characterized by inflammation of the nasal
2022-05-19
Allergic rhinitis, characterized by inflammation of the nasal membrane, results from an over-activated immune system exposed to SMER 3 in sensitized individuals, and is associated with nasal congestion, rhinorrhea, sneezing, and pruritus. As histamine is a key mediator in triggering allergic rhinit
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There have been a few studies investigating the effects
2022-05-19
There have been a few studies investigating the effects of histamine on mast cells but the majority of these has been on rodent and cultured mast cells (Hofstra et al., 2003, Lippert et al., 2004, Jemima et al., 2014). How representative these systems are of primary human cells is a moot point since
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br Methods br Involvement of HO in
2022-05-19
Methods Involvement of HO-1 in rheumatic diseases Therapeutic strategy targeted HO-1 Based on the researches focusing on the effect of HO-1 in rheumatic diseases, amount of approaches targeting regulation of HO-1 have been arising (See Table 1 for summary). It has been shown that different
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trpv br Conclusion The addition of cellulose to natural
2022-05-18
Conclusion The addition of trpv to natural substrate increases the number of H-bonds which indicates an increase in the stability of the docking systems. The investigated compounds are more stable than natural substrate in docking systems, where the natural substrate has two H-bonds while the in
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