• br Acknowledgements br Introduction Obesity is a

  2022-05-18

  

  Acknowledgements Introduction Obesity is a growing pandemic, which becomes a global public health problem. The evidence has been readily available and mounting, demonstrating that obesity increases incidences of chronic comorbidities, such as non-alcoholic fatty liver diseases, diabetes, cardi

• br Functional organization of postsynaptic glutamate recepto

  2022-05-18

  

  Functional organization of postsynaptic glutamate receptors Downstream effects of glutamate receptor positioning Mechanisms underlying the subsynaptic positioning of glutamate receptors Conclusions and future prospects The molecular organization of synapses is undoubtedly a critical dete

• br Method br Results br Discussion

  2022-05-18

  

  Method Results Discussion There were two major sources of fluorescent signals of NADH in the mouse retina. One was a product derived from glutamate and the other was the elevation of intrinsic NADH. In the present study, we observed significant contamination from intrinsic NADH in “the oute

• (±)-CPSI 1306 The role of the ER EK variant which is as

  2022-05-18

  

  The role of the ER22/23EK variant which is associated with relative resistance to GC, as shown by a reduction of transactivating capacity in vitro and less suppression of (±)-CPSI 1306 levels after 1mg DST in vivo. Relative GC resistance associated with the ER22/23EK polymorphism might protect from

• Different responses in feed intake have been noticed followi

  2022-05-18

  

  Different responses in feed intake have been noticed following administration of exogenous GHRL (peripherally or centrally) depending on animal species. In mammals, injection of GHRL stimulates food intake (orexigenic effect) (reviewed in Kaiya et al., 2013b). In contrast, in domestic birds, exogeno

• The recent identification of new

  2022-05-17

  

  The recent identification of new mechanisms for triggering ferroptosis, by compounds termed FIN56 and FINO2, provided new insights into regulation of ferroptosis. FINO2 acts through a distinct mechanism: it promotes lipid peroxidation by oxidizing iron and indirectly inactivating GPX4 [180]. FIN56 w

• Hyperhomocysteinemia HHcy is a clinical condition characteri

  2022-05-17

  

  Hyperhomocysteinemia (HHcy) is a clinical condition characterized by increased levels of plasma homocysteine (Hcy) and a well-known risk factor for CVDs. Hcy is a sulfur-containing non-protein amino tetrandrine australia formed during the intracellular conversion of methionine to cysteine. Previous

• Genome wide binding and transcriptome analyses demonstrate t

  2022-05-17

  

  Genome-wide binding and transcriptome analyses demonstrate that Fbxl10 directly binds the Areg, Mdk, Lmnb1, Thbs1, Mgp and Cxcl12 locus and thereby might influences the expression of these migration associated genes. The expression of epidermal growth factor (EGF)-like molecule Amphiregulin (Areg)

• Experimental conditions may be critical to explain one model

  2022-05-17

  

  Experimental conditions may be critical to explain one model or the other. The matter of Hippo-driven cytoplasmic sequestration (Varelas et al., 2008) of active SMAD complexes (Varelas et al., 2008) vs. TßR basolateral relocalization upon epithelial polarization (Nallet-Staub et al., 2015) as mechan

• br Obesity tips to a systematic failure in

  2022-05-17

  

  Obesity tips to a systematic failure in the overall metabolic regulation; it is a major global health problem and is linked to several metabolic diseases such as (T2D) (see ), (NAFLD), and cardiovascular disorders. The prevalence of such metabolic disorders has increased dramatically worldwide ,

• Based on our results we propose three possible mechanisms

  2022-05-17

  

  Based on our results, we propose three possible mechanisms of HER2 loss after trastuzumab-based therapy (Fig. 3). The first possibility is a result of the differential effects of treatments on clonal subsets. In breast cancer, such selective pressure has been suggested to preferentially eradicate HE

• Acknowledgement This work was supported by grants from the N

  2022-05-17

  

  Acknowledgement This work was supported by grants from the National Natural Science Foundation of China (No.81802749), Shenzhen Healthcare Research Project (No.SZBC2017029), the Science and Technology Foundation of Shenzhen (JCYJ20170412155231633, JSGG20170414104216477), National Key Research and D

• br Pathophysiology of glaucoma Glaucoma is a

  2022-05-17

  

  Pathophysiology of glaucoma Glaucoma is a group of optic neuropathies defined by progressive degeneration of RGCs and their cp-690550 in the optic nerve, which leads to irreversible loss of vision [3,8,9]. RGC degeneration is often significantly advanced before changes in visual acuity and eviden

• br Author contributions br Acknowledgements

  2022-05-17

  

  Author contributions Acknowledgements The work was financially supported by a grant from the Investigator-Initiated Studies Program (Ref. #38124) from Merck Sharp & Dohme, and, in part, from Research Grants Council of the Hong Kong Special Administrative Region, China (Ref. No.: 14110314), awa

• As part of their ongoing effort in the field Kalypsis

  2022-05-17

  

  As part of their ongoing effort in the field, Kalypsis recently disclosed that quinazolinones 5 [49], imidazo[1,2-a] [1,2]diazepin 6 [50] and quinolines 7 [51] all had activity as small molecule modulators of TGR5 (Figure 4). Intercept, however, disclosed different bile GSA 10 synthesis derivatives

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