• Our results are the first to demonstrate that ERR acts

  2020-12-22

  

  Our results are the first to demonstrate that ERRγ acts as a catabolic regulator of cartilage degeneration and OA pathogenesis, and collectively support the idea that ERRγ could be a therapeutic target for OA Introduction DNA cytosine-5-methyltransferases (Dnmts) catalyze the methyl transfer fr

• In general terms PLA s participate in the Lands

  2020-12-22

  

  In general terms, PLA2s participate in the Lands cycle of phospholipid fatty 3,4-DAA australia recycling [1,15,25], whereby the fatty acid composition at the sn-2 position of phospholipids is tightly controlled by a balance between hydrolytic reactions mediated by PLA2s versus activation of the fre

• PI K Akt eNOS signaling is long

  2020-12-22

  

  PI3K-Akt-eNOS signaling is long been known as a cell survival pathway in cardiology [8]. Current study has shown that ginsenosides, which is demonstrated to exhibit cardioprotective effect in several aspects, prevented cardiac ischemia/reperfusion injury via upregulation of PI3K and phosphorylations

• br Material and methods br Results and

  2020-12-22

  

  Material and methods Results and discussion Conclusion The gene encoding the Bos taurus muscle enolase enzyme was successfully isolated and cloned in this study. Optimization of the cloning, gene ubiquitin activating enzyme and purification was performed and protein elution at 95% purity wa

• LDC1267 br Conflict of Interest br Statement of Authorship b

  2020-12-22

  

  Conflict of Interest Statement of Authorship Introduction Plant endopeptidases are involved in many important biological processes. Recent developments in molecular biological techniques have revealed trace amounts of endopeptidases play essential roles in plant development, turnover of pho

• However with regard to the involvement of PEP

  2020-12-22

  

  However, with regard to the involvement of PEP in neoplastic processes, few studies and restricted to a very limited number of different tumors have been carried out [4], [18], [19]. Therefore, in order to ascertain the possible role of this enzyme in pathological proliferative tissues, in the prese

• Most xenobiotics undergo biotransformation before being excr

  2020-12-22

  

  Most xenobiotics undergo biotransformation before being excreted. Such biotransformation is classified into two phases. In the first phase, the lipophilic substrate is oxidized by the cytochrome P-450 (CYP450) enzyme system, which introduces a single oxygen rat 4 into the molecule (Moutou et al., 1

• In pregnancy maternal uterine spiral artery SA remodeling

  2020-12-22

  

  In pregnancy, maternal uterine spiral artery (SA) remodeling is essential for ensuring efficient blood flow to the developing fetus. A subset of CD49a+Eomes+ decidual NK SC 79 (dNK) that actively secretes GFs, such as pleiotrophin and osteoglycin, have recently been described in humans and in mice.

• PF 04418948 br Results br Discussion Oxysterols and EBI have

  2020-12-22

  

  Results Discussion Oxysterols and EBI2 have received growing attention in the field of immunology, with works highlighting an important role for EBI2 in immune cell migration. However, these studies are mainly limited to animal models (Chalmin et al., 2015, Hannedouche et al., 2011, Kelly et a

• br Materials and methods br Results

  2020-12-22

  

  Materials and methods Results Discussion Innate immunity plays an essential role in the control and elimination of bacterial infection through production of inflammatory cytokines (Liu et al., 2015). Production of inflammatory cytokines requires the recognition of bacterial pathogen-associa

• Argatroban Historically covalent drugs have had

  2020-12-21

  

  Historically, covalent drugs have had great success (e.g., aspirin and penicillin), and covalent drugs have become a focus in anticancer and antiviral drug discovery (Kalgutkar and Dalvie, 2012, Singh et al., 2011). These compounds contain low reactivity warheads that allow covalent adducts to form

• Abrahamson and coworkers recently demonstrated a distinct ro

  2020-12-21

  

  Abrahamson and coworkers (2009) recently demonstrated a distinct role of the podocyte in preservation and production of mature GBM-components such as α3/4/5(IV)-chains. This group further verified that collagen receptors (integrins) are linked to the mCAP of podocytes. In accordance to this data, ou

• br As DAPK is dependent on Ca

  2020-12-21

  

  As DAPK1 is dependent on Ca2+/CaM for its activity, its role in induction of autophagy is Ca2+-dependent and will be described in Section 5.1. LRRK1 and 2 were however shown to regulate autophagy in numerous studies where the role of Ca2+ was not investigated, and these mechanisms will be describe

• The authors gratefully acknowledge financial support from

  2020-12-21

  

  The authors gratefully acknowledge financial support from the State of São Paulo Research Foundation (FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo), grants 2013/07600-3 and 2013/25658-9, and the National Council for Scientific and Technological Development (CNPq, Conselho Nacional de

• br Materials and methods br

  2020-12-21

  

  Materials and methods Results As shown in Table 1, blood urea nitrogen and serum creatinine levels were significantly elevated at both 1st and 7th days of pyelonephritis, when compared with those of the control group (P822 formation or intratubular neutrophils, while tubules showed mild dilat

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