• is one of the few parasites that

  2020-03-11

  

  is one of the few parasites that can be encysted and excysted and we tested the localization and role of HA-tagged gEno in both differentiations, using a recently developed integrated vector that introduces a C-terminal triple HA tag under the selection marker puromycin . The localization of HA-ta

• Whichever interactions are formed between the DS domains

  2020-03-11

  

  Whichever interactions are formed between the DS domains and the collagen ligand, they are expected to lead to structural changes within the DDR dimer that are propagated across the cell membrane to result in DDR autophosphorylation (Noordeen et al., 2006). Tight coupling of the extracellular confor

• br Materials and methods br Results br Discussion

  2020-03-10

  

  Materials and methods Results Discussion Oxidative stress is a disturbance in the balance of pro- and antioxidant species, resulting in oxidative damage to membrane proteins, lipids, and DNA. Oxidative stress is a predisposing factor for the progression of metabolic diseases and liver injur

• At baseline mutant allele frequency of EGFR in tissue

  2020-03-10

  

  At baseline, mutant allele frequency of EGFR in tissue and plasma samples did not correlated with anti-tumor response (Supplementary Fig. 1). Among 35 patients who were positive for cell-free DNA (cfDNA) at baseline, changes of cfDNA during treatment were analyzed. Negative conversion (NC) of cfDNA

• As in our earlier observations the PTPN SNP

  2020-03-10

  

  As in our earlier observations, the PTPN22 SNP affected the appearance of β-cell autoimmunity, but in contrast to our earlier report, only a borderline effect of the PTPN22 SNP on the progression to clinical disease was observed in the current analysis [22], [27]. The finding of an effect of the PTP

• br Results br Discussion The ubiquitin system

  2020-03-10

  

  Results Discussion The ubiquitin system has in recent years become an exciting area for drug discovery (Cohen and Tcherpakov, 2010), as multiple enzymatic steps within the ubiquitylation process are druggable. The potential of targeting the ubiquitin-proteasome pathway was first demonstrated i

• FOX proteins constitute a large class of transcription

  2020-03-10

  

  FOX proteins constitute a large class of transcription factors with multiple functions, from development and organogenesis to regulation of metabolic and immune functions. The Fox transcription factor is characterized by a 100-amino-acid wing helix or forkhead DNA-binding domain. In addition, the FO

• br Results br Discussion Previous

  2020-03-10

  

  Results Discussion Previous studies have mapped ABCF1 as a risk factor gene for rheumatoid arthritis and autoimmune pancreatitis (Ota et al., 2007, Richard et al., 1998). Additionally, recent genome-wide association studies have also associated ABCF1 with the risk of gout (Dong et al., 2017) a

• N acetylation by N acetyltransferase NAT is an important met

  2020-03-10

  

  N-acetylation by N-acetyltransferase (NAT) is an important metabolic pathway for some substances, and there are 2 functional NAT isoforms in humans—NAT1 and NAT2. Studies of etamicastat in healthy subjects showed an extensive N-acetylation of etamicastat to the inactive metabolite BIA 5-961, and a l

• calmodulin dependent protein kinase Another important consid

  2020-03-10

  

  Another important consideration with respect to drug conditioning suggested by the present findings is the observation of an attenuated calmodulin dependent protein kinase on the second extinction trial. Seemingly, if ERK measurements were made following a partial reduction in the conditioned respo

• 398 mg br Materials and methods br Results br Discussion

  2020-03-10

  

  Materials and methods Results Discussion Anti-EGFR therapy for epithelial carcinomas has important clinical significance, but widespread intrinsic or acquired resistance seriously affects efficacy. Mutation and heterodimerization of EGFR are the two main causes of resistance to anti-EGFR th

• br Results br Discussion Mucosal barriers are constitutively

  2020-03-10

  

  Results Discussion Mucosal barriers are constitutively challenged by various stimuli, and the homeostasis of mucosal barriers both at steady state and upon challenge are maintained by tissue-resident immune TPMPA (Kurashima et al., 2013, Okumura and Takeda, 2016). ILC3s are found in lymphoid

• The DNA damage response DDR is a cellular mechanism

  2020-03-10

  

  The DNA damage response (DDR) is a cellular mechanism that protects against DNA damage induced by endogenous and exogenous factors, it includes changes in cellular processes such as Gramine regulation, DNA damage repair, apoptosis and chromatin remodeling. In recent years, the DDR has been recogniz

• Dihydrofolate reductase DHFR is an excellent molecular

  2020-03-10

  

  Dihydrofolate reductase (DHFR) is an excellent molecular target for this study because it has been and is currently studied by using different molecular modeling techniques [6], [7], [8], [9]. Kerrigan et al. have reported an interesting review about recent progress in molecular dynamics simulations

• br Protein acetylation Several reports show

  2020-03-10

  

  Protein acetylation Several reports show that MTX is able to induce acetylation of histones and other proteins. Extensive studies have established that histone acetylation is primarily associated with gene activation. Acetylation occurs at lysine residues on the amino-terminal tail of the protein

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